Pseudorabies virus US3-mediated inhibition of apoptosis does not affect infectious virus production
نویسندگان
چکیده
منابع مشابه
Role of pseudorabies virus Us3 protein kinase during neuronal infection.
The pseudorabies virus (PRV) Us3 gene is conserved among the alphaherpesviruses and encodes a serine/threonine protein kinase that is not required for growth in standard cell lines. In this report, we used a compartmented culture system to investigate the role of PRV Us3 in viral replication in neurons, in spread from neurons to PK15 cells, and in axon-mediated spread of infection. We also exam...
متن کاملPseudorabies virus US3 protein kinase mediates actin stress fiber breakdown.
Disruption of specific components of the host cytoskeleton has been reported for several viruses and is thought to be beneficial for viral replication and spread. Our previous work demonstrated that infection of swine kidney (SK-6) cells with pseudorabies virus (PRV), a swine alphaherpesvirus, induced actin stress fiber breakdown. In the present study, using several PRV deletion mutants, we fou...
متن کاملCEACAM1-Mediated Inhibition of Virus Production
Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respec...
متن کاملPseudorabies Virus
Etiology • Pseudorabies virus (PRV) is an enveloped, double-stranded DNA virus belonging to the family Herpesviridae. Also known as suid herpesvirus-1 (SuHV-1), the virus causes Aujeszky’s disease. • ‘Classical’ PRV strains affecting multiple species were first isolated in the early 1900s. ‘Variant’ PRV strains emerged in swine in China in 2011. • Genomic sequencing and phylogenetic analyses ha...
متن کاملPseudorabies Virus
Etiology • Pseudorabies virus (PRV) is an enveloped, double-stranded DNA virus belonging to the family Herpesviridae. Also known as suid herpesvirus-1 (SuHV-1), the virus causes Aujeszky’s disease. • ‘Classical’ PRV strains affecting multiple species were first isolated in the early 1900s. ‘Variant’ PRV strains emerged in swine in China in 2011. • Genomic sequencing and phylogenetic analyses ha...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2010
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.015297-0